LUPRON DEPOT-PED 45 mg for 6 months
Prepared and edited on behalf of the PES Drug & Therapeutics committee: Shilpa Mehta, MD, Amit Lahoti, MD, Aditi Khokar, MD, Anna Ryabets-Lienhard, DO, and Ryan Miller, MD
LUPRON DEPOT-PED® (leuprolide acetate for depot suspension) 45 mg for 6-month intramuscular injection is a GnRH analog (GnRHa) approved as a treatment for children with central precocious puberty (CPP). It has the same administration and features as 3-month and 1-month Lupron doses (prefilled dual chamber syringe along with Lupraloc safety technology/ 23-gauge 1.5-inch needle and injection volume of 1.5 ml; no refrigeration is required). Injection site reactions were the most common side effect. No head-to-head comparison studies with other GnRHa preparations are available to compare outcomes at this time.