Skip to content

To access the new portal/member content, please reset your username and password by clicking "I forgot my login name or password" on this page.

Pediatric Endocrine Society
  • Clinical
    Resources
    • Clinical Resource Library
    • Referral Guidelines
    • Special Interest Groups
    • Online Community
    • Insurance Appeal Letter Templates
    • And the survey says…
  • Patient
    Resources
    • What is a Pediatric Endocrinologist?
    • Patient Education
      • Patient Education Videos
    • Find a Pediatric Endocrinologist
    • Camps
    • Clinical Studies
    • Transition Toolkit
  • Education
    & Events
    • PES 50th Anniversary
    • Events Calendar
    • PES 2023 Annual Meeting
    • Board Review Course
    • Online Education
    • PES Leadership Advantage (PESLA)
    • Mentor Match Program
    • Fellows, Residents, and Students
      • PedsENDO365
      • PedsENDO Discovery Program
      • Practical Clinical Tools
      • Clinical Update and Case Discussion Course
      • Spring Fellows Retreat
      • ESPE E-Learning Web Portal
      • Mentoring Program
      • SEED
  • News &
    Publications
    • PES News & Announcements
    • Journal
  • Careers
    • Job Board
    • Pediatric Endocrine Program Directors
    • Certification
      • Maintenance of Certification (MOC)
      • Ethics in Pediatric Endocrinology MOC
      • PES Obesity SIG MOC/CME Activity
      • Precocious Puberty Self-Assessment MOC/CME
  • Grants
    & Awards
    • Senior Awards and Lectureships
    • Fellows and Junior Faculty Awards
    • Grants
  • About
    PES
    • About PES
      • Contact
      • Leadership
      • PES Committees
      • Society History
    • PES Membership
      • Join PES
    • Partner with Us
      • Mission Alliance Partners
      • Become a Mission Alliance Partner
      • PES Mission Alliance Partner Spotlight
      • Exhibit & Sponsorship Opportunities
      • Mailing List and Advertising
      • Conflict of Interest Statement
    • Policies and Strategy
      • Equity, Diversity and Inclusion Initiative
      • Strategic Plan
      • Policies and Bylaws
      • Public Policy and Advocacy
  • Join PES
  • Contact
  • Find a Pediatric Endocrinologist
  • Join PES
  • Contact
  • Find a Pediatric Endocrinologist
Pediatric Endocrine Society
Member Login
  • Clinical
    Resources
    • Clinical Resource Library
    • Referral Guidelines
    • Special Interest Groups
    • Online Community
    • Insurance Appeal Letter Templates
    • And the survey says…
  • Patient
    Resources
    • What is a Pediatric Endocrinologist?
    • Patient Education
      • Patient Education Videos
    • Find a Pediatric Endocrinologist
    • Camps
    • Clinical Studies
    • Transition Toolkit
  • Education
    & Events
    • PES 50th Anniversary
    • Events Calendar
    • PES 2023 Annual Meeting
    • Board Review Course
    • Online Education
    • PES Leadership Advantage (PESLA)
    • Mentor Match Program
    • Fellows, Residents, and Students
      • PedsENDO365
      • PedsENDO Discovery Program
      • Practical Clinical Tools
      • Clinical Update and Case Discussion Course
      • Spring Fellows Retreat
      • ESPE E-Learning Web Portal
      • Mentoring Program
      • SEED
  • News &
    Publications
    • PES News & Announcements
    • Journal
  • Careers
    • Job Board
    • Pediatric Endocrine Program Directors
    • Certification
      • Maintenance of Certification (MOC)
      • Ethics in Pediatric Endocrinology MOC
      • PES Obesity SIG MOC/CME Activity
      • Precocious Puberty Self-Assessment MOC/CME
  • Grants
    & Awards
    • Senior Awards and Lectureships
    • Fellows and Junior Faculty Awards
    • Grants
  • About
    PES
    • About PES
      • Contact
      • Leadership
      • PES Committees
      • Society History
    • PES Membership
      • Join PES
    • Partner with Us
      • Mission Alliance Partners
      • Become a Mission Alliance Partner
      • PES Mission Alliance Partner Spotlight
      • Exhibit & Sponsorship Opportunities
      • Mailing List and Advertising
      • Conflict of Interest Statement
    • Policies and Strategy
      • Equity, Diversity and Inclusion Initiative
      • Strategic Plan
      • Policies and Bylaws
      • Public Policy and Advocacy
  • Join PES
  • Contact
  • Find a Pediatric Endocrinologist

Effect of Growth Hormone Treatment on Adult Height in Peripubertal Children with Idiopathic Short Stature: A Randomized, Doubleblind, Placebo-Controlled Trial (The Journal of Clinical Endocrinology and Metabolism)

Home / Clinical Resources / Paper / Effect of Growth Hormone Treatment on Adult Height in Peripubertal Children with Idiopathic Short Stature: A Randomized, Doubleblind, Placebo-Controlled Trial (The Journal of Clinical Endocrinology and Metabolism)

Clinical Topic

  • Growth
    • Impaired Growth

Resource Type

  • Paper

Publication Date

July 1, 2004

Resource Link

View This Resource

Idiopathic Short Stature (ISS) is a kind of low height among children in which children’s height is more than 2 standard deviation (SD) scores below the mean score of the height of other children with the same age and gender. It is one of the disorders that physicians use growth hormone for its treatment.

Therefore, the purpose of the current study was to investigate the effect of growth hormone treatment on the adulthood height of children with ISS through meta-analysis method. In total 20 studies with a sample size of 1,517 were included in the meta-analysis through searching in external databases, including Web of science, Pubmed, Cochran, Medline, Embase, Springer, Scopus, and Science Direct using mesh keywords as growth hormone, final height, adult height, and idiopathic short stature. Mean score and SD were utilized for measuring any increase in height growth and random effect model was used for combining studies. Further, I2 index was used for determining the heterogeneity of studies.

Results indicated that before treatment, according to standard mean difference percentile of children’s height was -1.64 (95% confidence interval (CI): -2.01 to -1.28) which is equal to 5%. After treatment, according to standard mean difference percentile of children’s height came out to be 0.11 (95% CI: 0.07 – 0.14) which is equal to 54.38%.

This indicates that percentile of children’s height has increased as a result of treatment with growth hormone. Through combining the results of all studies, the mean score for participants’ height before treatment was 5% and after treatment it reached 54%. Therefore, obtained mean difference for adult height after treatment with growth hormone was reported to be more than 1.4 SD score (about 7.6 cm). Growth hormone can be influential in increasing the adult height of children with ISS.

Get Involved

Join a Special Interest Group

Learn More

Join PES

Learn More

Mentoring Program

Learn More

Explore PES Grants & Scholarships

Learn More

pes-white-logo

6728 Old McLean Village Dr
McLean, Virginia 22101
Phone: (703) 884-9781
info@pedsendo.org

  • Clinical
    Resources
    • Clinical Resource Library
    • Referral Guidelines
    • Special Interest Groups
    • Online Community
    • Insurance Appeal Letter Templates
    • And the survey says…
  • Patient
    Resources
    • What is a Pediatric Endocrinologist?
    • Patient Education
      • Patient Education Videos
    • Find a Pediatric Endocrinologist
    • Camps
    • Clinical Studies
    • Transition Toolkit
  • Education
    & Events
    • PES 50th Anniversary
    • Events Calendar
    • PES 2023 Annual Meeting
    • Board Review Course
    • Online Education
    • PES Leadership Advantage (PESLA)
    • Mentor Match Program
    • Fellows, Residents, and Students
      • PedsENDO365
      • PedsENDO Discovery Program
      • Practical Clinical Tools
      • Clinical Update and Case Discussion Course
      • Spring Fellows Retreat
      • ESPE E-Learning Web Portal
      • Mentoring Program
      • SEED
  • News &
    Publications
    • PES News & Announcements
    • Journal
  • Careers
    • Job Board
    • Pediatric Endocrine Program Directors
    • Certification
      • Maintenance of Certification (MOC)
      • Ethics in Pediatric Endocrinology MOC
      • PES Obesity SIG MOC/CME Activity
      • Precocious Puberty Self-Assessment MOC/CME
  • Grants
    & Awards
    • Senior Awards and Lectureships
    • Fellows and Junior Faculty Awards
    • Grants
  • About
    PES
    • About PES
      • Contact
      • Leadership
      • PES Committees
      • Society History
    • PES Membership
      • Join PES
    • Partner with Us
      • Mission Alliance Partners
      • Become a Mission Alliance Partner
      • PES Mission Alliance Partner Spotlight
      • Exhibit & Sponsorship Opportunities
      • Mailing List and Advertising
      • Conflict of Interest Statement
    • Policies and Strategy
      • Equity, Diversity and Inclusion Initiative
      • Strategic Plan
      • Policies and Bylaws
      • Public Policy and Advocacy
  • Join PES
  • Contact
  • Find a Pediatric Endocrinologist
  • Contact
  • Join PES

Learn More About PES!

Contact Us

© 2023 Pediatric Endocrine Society     Privacy Policy     Accessibility Statement

Website by Yoko Co

Scroll To Top